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Báo cáo y học: "Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:""Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs. | Respiratory Research BioMed Central Open Access Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs Megan J Wallace 1 Megan E Probyn1 Valerie A Zahra1 Kelly Crossley1 Timothy J Cole2 Peter G Davis3 Colin J Morley3 and Stuart B Hooper1 Address Department of Physiology Monash University Melbourne Victoria Australia 2Department of Biochemistry and Molecular Biology Monash University Melbourne Victoria Australia and 3Newborn Research Royal Women s Hospital Melbourne Victoria Australia Email Megan J Wallace - megan.wallace@med.monash.edu.au Megan E Probyn - m.probyn@uq.edu.au Valerie A Zahra - valerie.zahra@med.monash.edu.au Kelly Crossley-kelly.crossley@med.monash.edu.au Timothy J Cole - tim.cole@med.monash.edu.au Peter G Davis - pgd@unimelb.edu.au Colin J Morley - colin@morleys.net Stuart B Hooper - stuart.hooper@med.monash.edu.au Corresponding author Published 10 March 2009 Received 28 November 2008 Respiratory Research 2009 10 19 doi l0.ll86 l465-992l-l0-l9 Accepted I0 March 2009 This article is available from http respiratory-research.cOm content l0 l l9 2009 Wallace et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bronchopulmonary dysplasia BPD is closely associated with ventilator-induced lung injury VILI in very preterm infants. The greatest risk of VILI may be in the immediate period after birth when the lungs are surfactant deficient still partially filled with liquid and not uniformly aerated. However there have been very few studies that have examined this immediate post-birth period and identified the initial injury-related pathways that are activated. We aimed to determine if the early response genes connective tissue growth factor CTGF cysteine