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Báo cáo y học: " Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation. | Respiratory Research BioMed Central Open Access Review Endothelial cells and pulmonary arterial hypertension apoptosis proliferation interaction and transdifferentiation Seiichiro Sakao 1 Koichiro Tatsumi1 and Norbert F Voelkel2 Address Departmentof Respirology B2 Graduate School of Medicine Chiba University 1-8-1 Inohana Chuo-ku Chiba 260-8670 Japan and 2Victoria Johnson Center for Obstructive Lung Diseases and Pulmonary and Critical Care Medicine Division Virginia Commonwealth University 1101 East Marshall Street Sanger Hall Richmond Virginia 23298-0565 USA Email Seiichiro Sakao - sakaos@faculty.chiba-u.jp Koichiro Tatsumi - tatsumi@faculty.chiba-u.jp Norbert F Voelkel - nvoelkel@mcvh-vcu.edu Corresponding author Published 13 October 2009 Received 22 April 2009 Respiratory Research 2009 10 95 doi 10.1186 1465-9921-10-95 Accepted I3 October 2009 This article is available from http respiratory-research.com content 10 1 95 2009 Sakao et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Severe pulmonary arterial hypertension whether idiopathic or secondary is characterized by structural alterations of microscopically small pulmonary arterioles. The vascular lesions in this group of pulmonary hypertensive diseases show actively proliferating endothelial cells without evidence of apoptosis. In this article we review pathogenetic concepts of severe pulmonary arterial hypertension and explain the term complex vascular lesion commonly named plexiform lesion with endothelial cell dysfunction i.e. apoptosis proliferation interaction with smooth muscle cells and transdifferentiation. Introduction Severe pulmonary arterial hypertension PAH whether idiopathic or associated with known causes secondary forms may have a .