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Báo cáo y học: "Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-a blockade in the knee joint"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-a blockade in the knee joint. | Fiocco et al. Arthritis Research Therapy 2010 12 R148 http arthritis-research.eom content 12 4 R148 RESEARCH ARTICLE Open Access Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-a blockade in the knee joint 1 1 1 2 3 1 Ugo Fiocco Paolo Sfriso Francesca Oliviero Pascale Roux-Lombard Elena Scagliori Luisella Cozzi 3 3 1 r- P s 1 1 1 Francesca Lunardi Fiorella Calabrese Maristella Vezzù Serena Dainese Beatrice Molena Anna Scanu Pr Horỳm kta rrl H i nn o4 I D iPtTỉlỳolli3 I Cl rì l l PItỉx or5 I 3rH I Diir i 7Í1 Roberto Nardacchione Leopoldo Rubaltelli Jean Michel Dayer Leonardo Punzi Abstract Introduction The purpose of this study was theevaluation of synovial effusion SE synovial fluid SF and synovial tissue ST biomarkers in relation to disease activity indexes to assess the response to intraarticular IA tumor necrosis factor TNF -a blockers in psoriatic arthritis PsA . Methods Systemic and local disease activity indexes disease activity score DAS the Ritchie articular index mRAI erythrocyte sedimentation rate ESR and C-reactive protein CRP Thompson articular THOMP and joint articular KJAI -Index and ST samples were assessed at baseline throughout treatment and during the follow-up in 14 patients affected with PsA who underwent IA injections 0.5 ml to 12.5 mg in the knee joint of etanercept E or placebo P once every two weeks for a 10-week period. Total SF white blood cell WBC counts WBC gl and SF cytokine chemokine CK CCK levels were measured before IA-E at baseline after IA-E and as long as there were adequate amounts of SF for knee aspiration post . Characterization of synovial mononuclear cell infiltration and synovial vessels was carried out in 8 out of 14 knees by staining serial sections of synovial tissue biopsies for CD45 CD3 CD68 CD31 and CD105. Results At baseline CRP and or ESR were significantly correlated with SF-CK interleukin- IL- 1p IL-1Ra IL-6 IL-8 and CCK CCL3 . Post-IA injections