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Báo cáo y học: " Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis. | Respiratory Research BioMed Central Research Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis Angela Trovato-Salinaro2 Elisa Trovato-Salinaro1 Marco Failla1 Claudio Mastruzzo1 Valerio Tomaselli1 Elisa Gili1 Nunzio Crimi1 Daniele Filippo Condorelli2 and Carlo Vancheri 1 Open Access Address Department of Internal Medicine and Specialistic Medicine Section of Respiratory Diseases University of Catania Catania Italy and 2Department of Chemical Sciences Section of Biochemistry and Molecular Biology University of Catania Catania Italy Email AngelaTrovato-Salinaro - A.salinaro@unict.it Elisa Trovato-Salinaro - E.salinaro@unict.it Marco Failla - marcofailla@yahoo.it Claudio Mastruzzo - claudiomastruzzo@hotmail.com Valerio Tomaselli - v.tomaselli@unict.it Elisa Gili - elisagili@hotmail.com Nunzio Crimi - crimi@unict.it Daniele Filippo Condorelli - condorda@unict.it Carlo Vancheri - vancheri@unict.it Corresponding author Published 27 September 2006 Received 29 March 2006 Accepted 27 September 2006 Respiratory Research 2006 7 122 doi l0.ll86 l 465-9921-7-122 This article is available from http respiratory-research.cOm content 7 1 122 2006 Trovato-Salinaro et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Rationale Gap junctions are membrane channels formed by an array of connexins which links adjacent cells realizing an electro- metabolic synapse. Connexin-mediated communication is crucial in the regulation of cell growth differentiation and development. The activation and proliferation of phenotypically altered fibroblasts are central events in the pathogenesis of idiopathic