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Báo cáo y học: " Role of TNFα in pulmonary pathophysiology Srirupa Mukhopadhyay, John R Hoidal and Tapan K "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Role of TNFα in pulmonary pathophysiology Srirupa Mukhopadhyay, John R Hoidal and Tapan K. | Respiratory Research BioMed Central Open Access Role of TNFa in pulmonary pathophysiology Srirupa Mukhopadhyay John R Hoidal and Tapan K Mukherjee Address Pulmonary Division Department of Internal Medicine University of Utah Health Science Center Salt Lake City Utah 84132-4701 USA Email Srirupa Mukhopadhyay - srirupa_mu@yahoo.com John R Hoidal - john.hoidal@hsc.utah.edu Tapan K Mukherjee - tapan.mukherjee@hsc.utah.edu Corresponding author Published II October 2006 Received 23 May 2006 Respiratory Research 2006 7 125 doi 10.1186 1465-9921-7-125 Accepted 1 1 October 2006 This article is available from http respiratory-research.com content 7 1 125 2006 Mukhopadhyay et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Tumor necrosis factor alpha TNFa is the most widely studied pleiotropic cytokine of the TNF superfamily. In pathophysiological conditions generation of TNFa at high levels leads to the development of inflammatory responses that are hallmarks of many diseases. Of the various pulmonary diseases TNFa is implicated in asthma chronic bronchitis CB chronic obstructive pulmonary disease COPD acute lung injury ALI and acute respiratory distress syndrome ARDS . In addition to its underlying role in the inflammatory events there is increasing evidence for involvement of TNFa in the cytotoxicity. Thus pharmacological agents that can either suppress the production of TNFa or block its biological actions may have potential therapeutic value against a wide variety of diseases. Despite some immunological side effects anti-TNFa therapeutic strategies represent an important breakthrough in the treatment of inflammatory diseases and may have a