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Báo cáo y học: "Fibroblast growth factor 2: good or bad guy in the join"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Fibroblast growth factor 2: good or bad guy in the joint? | Vincent Arthritis Research Therapy 2011 13 127 http arthritis-research.eom content 13 5 127 EDITORIAL Fibroblast growth factor 2 good or bad guy in the joint Tonia L Vincent See related research by Yan etal. http arthritis-research.eom content 13 4 R130 Abstract Fibroblast growth factor 2 FGF2 is a highly abundant growth factor found within the pericellular matrix of articular chondrocytes but studies investigating its role have been conflicting. The paper reported by Yan and colleagues in the previous issue of Arthritis Research Therapy proposes that differences in responses to FGF2 are most likely due to changes in the balance between the two major articular cartilage FGF receptors FGFR1 and FGFR3. They show that the catabolic and anti-anabolic effects of FGF2 are mediated primarily through FGFR1 whereas the beneficial effects are through FGFR3. This balance is dynamic and is altered in disease and following growth factor stimulation in vitro. Fibroblast growth factor FGF 2 is a ubiquitously expressed pleiotropic growth factor with many recognised cellular targets and tissue effects. Its role in articular chondrocytes and mesenchymal cells has been extensively studied but published data are plagued by apparent contradiction and inconsistency. The paper by Yan and colleagues reported in the previous issue of Arthritis Research Therapy proposes a novel and elegant explanation for these seemingly disparate and conflicting findings 1 . FGFs signal through one of four FGF receptors FGFRs and the authors show that the catabolic effects of FGF2 induction of proteases such as matrix metalloproteinase 13 MMP13 and ADAMTS5 a disintegrin and metalloproteinase with thrombospondin motifs 5 as well as suppression of matrix synthesis are specifically mediated through FGFR1 ligation. They propose that FGF2 signalling via FGFR3 the other major cell surface receptor on chondrocytes leads to a dominant anabolic Correspondence tonia.vincent@kennedy.ox.ac.uk Kennedy Institute of .