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Báo cáo y học: "The effect of continuous positive airway pressure (CPAP) on renal vascular resistance: the influence of renal denervation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The effect of continuous positive airway pressure (CPAP) on renal vascular resistance: the influence of renal denervation. | Research paper 33 The effect of continuous positive airway pressure CPAP on renal vascular resistance the influence of renal denervation Rose A Sharkey Eithne MT Mulloy Michelle Long and Shane J O Neill Objective To non-invasively study the effects of continuous positive airway pressure breathing CPAP on renal vascular resistance in normal subjects and renal allograft recipients in other words those with with denervated kidneys. We could then ascertain the influence of renal innervation on any resulting changes in renal haemodynamics. Methods Ten healthy volunteers and six renal transplant patients were studied. Using Doppler ultrasonography the pulsatility index PI an index of renovascular resistance was measured at incremental levels of CPAP 0 2.5 5.0 and 7.5 cmH2O . Results In both groups the PI increased significantly between 0 and 5.0cmH2O CPAP with a further increase at 7.5 cmH2O CPAP. Conclusions We found that CPAP at 5.0 and 7.5 cmH2O caused a significant increase in renovascular resistance in both normal and renal transplant patients. There was no difference in the degree of rise in renovascular resistance between both groups indicating that the renal nerves do not play a role in altering renal vascular resistance with the application of CPAP. Address Department of Respiratory Medicine Beaumont Hospital Dublin 9 Ireland. Correspondence Dr Shane O Neill Department of Respiratory Medicine Beaumont Hospital Dublin 9 Ireland. Tel 01 8377755 fax 01 8376982 Keywords continuous positive airway pressure renal denervation renal vascular resistance Received 11 February 1998 Revisions requested 27 April 1998 Revisions received 17 June 1998 Accepted 9 February 1999 Published 16 March 1999 Crit Care 1999 3 33-37 The original version of this paper is the electronic version which can be seen on the Internet http ccforum.com . The electronic version may contain additional information to that appearing in the paper version. Current Science Ltd ISSN 1364-8535 Introduction .