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Báo cáo y học: "What is the role of surfactant and inhaled nitric oxide in lung transplantation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: What is the role of surfactant and inhaled nitric oxide in lung transplantation? | Critical Care June 2002 Vol 6 No 3 Struber Commentary What is the role of surfactant and inhaled nitric oxide in lung transplantation Martin Struber Staff Surgeon Hannover Thoracic Transplant Program Division of Thoracic and Cardiovascular Surgery Hannover Medical School Germany Correspondence Martin Struber strueber@thg.mh-hannover.de Published online 9 May 2002 Critical Care 2002 6 186-187 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Although numerous studies over the past 40 years have addressed this problem initial graft failure is still a key question in clinical lung transplantation. As a possible tool to avoid and treat initial graft failure after lung transplantation laboratory evidence and clinical reports currently emphasize the role of substitution therapy of surfactant combined with inhaled nitric oxide. Keywords lung transplantation nitric oxide reperfusion injury surfactant The case report by Della Rocca and coworkers published in this issue of Critical Care 1 describes the occurrence of severe reperfusion injury after lung transplantation and successful treatment using a combination of inhaled nitric oxide iNO and surfactant instillation. What is the role of surfactant in management of initially impaired graft function after lung transplantation and do these findings apply to other forms of lung injury Ischaemia reperfusion injury leading to initial graft failure is a major cause of early mortality after lung transplantation. In addition this problem led to the exclusion of most organ donors from lung harvesting because acceptance criteria selected only optimal grafts. A shortage of suitable lung grafts became the rate-limiting step to lung transplantation 2 . Numerous studies were performed to avoid or ameliorate ischaemia reperfusion injury. As early as 1991 Novick and coworkers 3 reported on alterations in surface activity of surfactant in experimental lung transplantation. Subsequent work 4 revealed an increase in .