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Báo cáo y học: " Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:ttenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. | Respiratory Research BioMed Central Research Open Access Attenuated allergic airway hyperresponsiveness in C57BL 6 mice is associated with enhanced surfactant protein SP -D production following allergic sensitization Elena N Atochina Michael F Beers Yaniv Tomer Seth T Scanlon Scott J Russo Reynold A Panettieri Jr and Angela Haczku Address Pulmonary Allergy Critical Care Division Department of Medicine University of Pennsylvania School of Medicine Philadelphia PA USA Email Elena N Atochina- haczku@mail.med.upenn.edu Michael F Beers - haczku@mail.med.upenn.edu Yaniv Tomer - haczku@mail.med.upenn.edu Seth T Scanlon - haczku@mail.med.upenn.edu Scott J Russo - haczku@mail.med.upenn.edu Reynold A Panettieri - haczku@mail.med.upenn.edu Angela Haczku - haczku@mail.med.upenn.edu Corresponding author Published 08 December 2003 Received 18 September 2003 Accepted 08 December 2003 Respiratory Research 2003 4 15 This article is available from http respiratory-research.cOm content 4 l l5 2003 Atochina et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background C57BL 6 mice have attenuated allergic airway hyperresponsiveness AHR when compared with Balb c mice but the underlying mechanisms remain unclear. SP-D an innate immune molecule with potent immunosuppressive activities may have an important modulatory role in the allergic airway response and the consequent physiological changes. We hypothesized that an elevated SP-D production is associated with the impaired ability of C57BL 6 mice to develop allergic AHR. Methods SP-D mRNA and protein expression was investigated during development of allergic airway changes in a model of Aspergillus fumigatus Af -induced allergic inflammation. To study whether strain dependency of allergic AHR is associated with different levels of SP-D in the lung