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Báo cáo khoa học: "The effect of oral sodium acetate administration on plasma acetate concentration and acid-base state in horses"

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú y đề tài: The effect of oral sodium acetate administration on plasma acetate concentration and acid-base state in horses. | Acta Veterinaria Scandinavica BioMed Central Research The effect of oral sodium acetate administration on plasma acetate concentration and acid-base state in horses Amanda Waller and Michael I Lindinger Open Access Address Dept. of Human Health and Nutritional Sciences University of Guelph Guelph ON N1G 2W1 Canada Email Amanda Waller - awaller@uoguelph.ca Michael I Lindinger - mlinding@uoguelph.ca Corresponding author Published 20 December 2007 Received 4 October 2007 J .1 n I I n 11 I n IA A n n Accepted 20 December 2007 Acta Veterinaria Scandinavica 2007 49 38 doi 10.1186 1751-0147-49-38 This article is available from http www.actavetscand.cOm content 49 1 38 2007 Waller and Lindinger licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Aim Sodium acetate NaAcetate has received some attention as an alkalinizing agent and possible alternative energy source for the horse however the effects of oral administration remain largely unknown. The present study used the physicochemical approach to characterize the changes in acid-base status occurring after oral NaAcetate acetic acid NAA administration in horses. Methods Jugular venous blood was sampled from 9 exercise-conditioned horses on 2 separate occasions at rest and for 24 h following a competition exercise test CET designed to simulate the speed and endurance test of 3-day event. Immediately after the CETs horses were allowed water ad libitum and either I 8 L of a hypertonic NaAcetate acetic acid solution via nasogastric tube followed by a typical hay grain meal NAA trial or 2 a hay grain meal alone Control trial . Results Oral NAA resulted in a profound plasma alkalosis marked by decreased plasma H and increased plasma TCO2 and HCO3- compared to Control. The primary .