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Báo cáo y học: "Coagulation cascade in sepsis: getting from bench to bedside"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Coagulation cascade in sepsis: getting from bench to bedside? | Available online http ccforum.eom content 7 2 117 Commentary Coagulation cascade in sepsis getting from bench to bedside Glen Brown Clinical Coordinator Pharmacy Department St. Paul s Hospital Vancouver British Columbia Canada Correspondence Glen Brown gbrown@providencehealth.bc.ca Published online 6 November 2002 Critical Care 2003 7 117-118 DOI 10.1186 cc1842 This article is online at http ccforum.com content 7 2 117 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract The relationship between blood coagulation factors and the promotion or inhibition of the antiinflammatory response continues to be defined through basic research. The potential key role of blood coagulation factors in the response during sepsis provides an exciting potential mechanism s for modification through the application of new therapies. The complexity of the potential multiple actions of the proteins such as protein C should allow for development of new therapies to minimize the detrimental inflammatory response. However several gaps in our current understanding must be bridged before the clinician can take the basic knowledge to the bedside where individual patients will benefit. Keywords blood coagulation factors protein C sepsis The relationship between the clotting cascade and the promotion or inhibition of the anti-inflammatory response continues to be defined through basic research. The potential key role of proteins that were originally believed to be exclusively involved in coagulation in the inflammatory response provides an exciting potential mechanism s for modification through the application of new therapies. The accompanying review by Riewald and Ruf 1 outlines the available information on the possible steps involving some of the various proteins that are common to both coagulation and inflammation. The complexity of the multiple actions of the proteins in both inflammation and coagulation should excite the clinician with regard to potential new .