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Báo cáo khoa học: "The role of cardiac troponin I as a prognosticator in critically ill medical patients: a prospective observational cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The role of cardiac troponin I as a prognosticator in critically ill medical patients: a prospective observational cohort study. | Available online http ccforum.eom content 9 4 R390 Research The role of cardiac troponin I as a prognosticator in critically ill medical patients a prospective observational cohort study Daniel A King Shlomi Codish Victor Novack Leonid Barski and Yaniv Almog Open Access Medical Intensive Care Unit Soroka University Medical Center and the Faculty of Health Sciences Ben-Gurion University Beer Sheva Israel Corresponding author Yaniv Almog almogya@bgu.ac.il Received 13 Feb 2005 Revisions requested 16 Mar 2005 Revisions received 30 Mar 2005 Accepted 7 May 2005 Published 31 May 2005 Critical Care 2005 9 R390-R395 DOI 10.1186 cc3731 This article is online at http ccforum.com content 9 4 R390 2004 King et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract Introduction Myocardial injury is frequently unrecognized in intensive care unit ICU patients. Cardiac troponin I cTnl a surrogate of myocardial injury has been shown to correlate with outcome in selected groups of patients. We wanted to determine if cTnI level measured upon admission is an independent predictor of mortality in a heterogeneous group of critically ill medical patients. Methods We conducted a prospective observational cohort study 128 consecutive patients admitted to a medical ICU at a tertiary university hospital were enrolled. cTnl levels were measured within 6 h of admission and were considered positive 0.7 ng ml or negative. A variety of clinical and laboratory variables were recorded. Results Both cTnl positive and negative groups were similar in terms of age sex and pre-admission co-morbidity. In a univariate analysis positive cTnl was associated with increased mortality OR 7.0 95 Cl 2.44-20.5 p 0.001 higher Acute Physiology and Chronic Health Evaluation .