Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo khoa học: "Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat. | Available online http ccforum.eom content 10 6 R157 Research Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat Christian Lehmann 1 Konrad Meissner2 Andreas Knock1 Stephan Diedrich1 Dragan Pavlovic1 Matthias Grundling1 Taras Usichenko1 Michael Wendt1 and Jurgen Birnbaum3 1Klinik und Poliklinik fur Anasthesiologie und Intensivmedizin Ernst Moritz Arndt University Fr.-Loeffler-Str. 23a D-17475 Greifswald Germany 2Washington University Medical Center Department of Anesthesiology 660 S. Euclid Ave. St. Louis MO 63110 USA 3Charité - Universitatsmedizin Berlin Kliniken fur Anasthesiologie und operative Intensivmedizin Campus Charité Mitte Chariteplatz 1 D-10117 Berlin Germany Corresponding author Christian Lehmann christian.lehmann@uni-greifswald.de Received 7 Aug 2006 Revisions requested 8 Sep 2006 Revisions received 21 Sep 2006 Accepted 13 Nov 2006 Published 13 Nov 2006 Critical Care 2006 10 R157 doi 10.1186 cc5093 This article is online at http ccforum.com content 10 6 R157 2006 Lehmann et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Successful treatment of severe sepsis and septic shock remains a major challenge in critical care medicine. The recently introduced recombinant human activated protein C APC remarkably improved the outcome of septic patients. The influence of APC on intestinal circulation is still poorly understood. Therefore the present study aimed to investigate the effects of APC on intestinal microcirculation during experimental endotoxaemia in rats by using intravital microscopy. Methods A total of 44 male Lewis rats were randomly assigned to receive intravenous injections of 15 mg kg lipopolysaccharide alone LPS n 11 or LPS