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Báo cáo y học: "An overview of the sensory receptors regulating cough"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: An overview of the sensory receptors regulating cough. | Cough BioMed Central Review An overview of the sensory receptors regulating cough Stuart B Mazzone Open Access Address Howard Florey Institute University of Melbourne Parkville VIC 3010 Australia Email Stuart B Mazzone - s.mazzone@hfi.unimelb.edu.au Corresponding author Published 04 August 2005 Received 04 April 2005 Cough 2005 1 2 doi 10.1186 1745-9974-1-2 Accepted 04 August 2005 This article is available from http www.coughjournal.cOm content 1 1 2 2005 Mazzone licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The cough reflex represents a primary defensive mechanism for airway protection in a variety of mammalian species. However excessive and inappropriate coughing can emerge as a primary presenting symptom of many airway diseases. Cough disorders are characterized by a reduction in the threshold for reflex initiation and as a consequence the occurrence of cough in response to stimuli that are normally innocuous in nature. The current therapeutic strategies for the treatment of cough disorders are only moderately effective. This undoubtedly relates in part to limitations in our understanding of the neural components comprising the cough reflex pathway. The aim of this review is to provide an overview of current concepts relating to the sensory innervation to the mammalian airways focusing particularly on the sensory receptors that regulate cough. In addition the review will highlight particular areas and issues relating to cough neurobiology that are creating controversy in the field. Introduction The basic nature of the respiratory system i.e. inspiration of air from the surrounding environment for gas exchange as well as the shared nature of the initial anatomical structures for the passage of food and air .