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Báo cáo y học: "A comparison of high-mobility group-box 1 protein, lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia: a prospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A comparison of high-mobility group-box 1 protein, lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia: a prospective study. | Available online http ccforum.eom content 11 4 R76 Research A comparison of high-mobility group-box 1 protein lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia a prospective study Shahin Gaini1 Ole G Koldkj r2 Holger J Moller3 Court Pedersen1 and Svend S Pedersen1 Department of Infectious Diseases Odense University Hospital Sondre Boulevard 29 DK-5000 Odense C Denmark department of Clinical Biochemistry Sonderborg Hospital Sonderborg Denmark department of Clinical Biochemistry AS-NBG Aarhus University Hospital Aarhus Denmark Corresponding author Shahin Gaini shahin.gaini@ouh.regionsddanmark.dk Received 27 Apr 2007 Revisions requested 31 May 2007 Revisions received 22 Jun 2007 Accepted 11 Jul 2007 Published 11 Jul 2007 Critical Care 2007 11 R76 doi 10.1186 cc5967 This article is online at http ccforum.com content 11 4 R76 2007 Gaini et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction High-mobility group box-1 protein HMGB1 has been known as a chromosomal protein for many years. HMGB1 has recently been shown to be a proinflammatory cytokine with a role in the immunopathogenesis of sepsis. Lipopolysaccharide-binding protein LBP has a central role in the innate immune response when the host is challenged by bacterial pathogens. Procalcitonin PCT has been suggested as a marker of severe bacterial infections and sepsis. The aim of the present study was to investigate levels of HMGB1 LBP and PCT in a well-characterised sepsis cohort. The study plan included analysis of the levels of the inflammatory markers in relation to the severity of infection to the prognosis and to the ability to identify patients with bacteraemia. Methods .