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Báo cáo y học: "Vasopressin improves survival in a porcine model of abdominal vascular inj"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Vasopressin improves survival in a porcine model of abdominal vascular injury. | Available online http ccforum.eom content 11 4 R81 Research Vasopressin improves survival in a porcine model of abdominal vascular injury Karl H Stadlbauer1 Horst G Wagner-Berger1 Anette C Krismer1 Wolfgang G Voelckel1 Alfred Konigsrainer2 Karl H Lindner1 and Volker Wenzel1 1 Department of Anaesthesiology and Critical Care Medicine Innsbruck Medical University Anichstrasse 6020 Innsbruck Austria 2Department of Surgery Eberhard-Karls Unversity Hoppe-Seyler-StraBe 72076 Tubingen Germany Corresponding author Karl H Stadlbauer karl-heinz.stadlbauer@i-med.ac.at Received 8 Mar 2007 Revisions requested 13 Apr 2007 Revisions received 19 Jul 2007 Accepted 23 Jul 2007 Published 23 Jul 2007 Critical Care 2007 11 R81 doi 10.1186 cc5977 This article is online at http ccforum.com content 11 4 R81 2007 Stadlbauer et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction We sought to determine and compare the effects of vasopressin fluid resuscitation and saline placebo on haemodynamic variables and short-term survival in an abdominal vascular injury model with uncontrolled haemorrhagic shock in pigs. Methods During general anaesthesia a midline laparotomy was performed on 19 domestic pigs followed by an incision width about 5 cm and depth 0.5 cm across the mesenterial shaft. When mean arterial blood pressure was below 20 mmHg and heart rate had declined progressively experimental therapy was initiated. At that point animals were randomly assigned to receive vasopressin 0.4 U kg n 7 fluid resuscitation 25 ml kg lactated Ringer s and 25 ml kg 3 gelatine solution n 7 or a single injection of saline placebo n 5 . Vasopressin-treated animals were then given a continuous infusion of 0.08 U kg per min vasopressin .