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Báo cáo y học: " Cellular turnover and expression of hypoxic-inducible factor in acute acalculous and calculous cholecystitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cellular turnover and expression of hypoxic-inducible factor in acute acalculous and calculous cholecystitis. | Available online http ccforum.eom content 11 5 R116 Research Cellular turnover and expression of hypoxic-inducible factor in acute acalculous and calculous cholecystitis Merja Vakkala1 Jouko J Laurila1 Juha Saarnio2 Vesa Koivukangas2 Hannu Syrjala3 Tuomo Karttunen4 Ylermi Soini4 and Tero I Ala-Kokko1 Department of Anesthesiology Division of Intensive Care Oulu University Hospital Kajaanintie 52 Oulu Finland FIN-90029 2Department of Surgery Oulu University Hospital Kajaanintie 52 Oulu Finland FIN-90029 3Department of Infection Control Oulu University Hospital Kajaanintie 52 Oulu Finland FIN-90029 4Department of Pathology Oulu University Kajaanintie 50 Oulu Finland FIN-90029 Corresponding author Tero I Ala-Kokko tak@cc.oulu.fi Received 24 Aug 2007 Revisions requested 24 Oct 2007 Revisions received 31 Oct 2007 Accepted 31 Oct 2007 Published 31 Oct 2007 Critical Care 2007 11 R116 doi 10.1186 cc6170 This article is online at http ccforum.com content 11 5 R116 2007 Vakkala et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Epithelial corrective and destructive mechanisms have not been studied in inflammatory gallbladder disease. Methods Epithelial apoptosis cell proliferation and expression of hypoxia-inducible factor HIF -1a were compared in gallbladders from patients with acute acalculous cholecystitis AAC n 30 and acute calculous cholecystitis ACC n 21 and from patients undergoing surgery for other reasons normal gallbladders n 9 which were removed during open cholecystectomy. The immunohistochemical stains included antibodies to Ki-67 proliferation M30 apoptosis and HIF-1a. Proliferation and apoptosis were expressed as percentages of positive cells. HIF-1a expression was expressed as .