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Báo cáo y học: " Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1 | Retrovirology BioMed Central Research Open Access Interactions between Nef and AIPI proliferate multivesicular bodies and facilitate egress of HIV-1 Luciana J Costa11 Nan Chent2 Adriana Lopes1 Renato S Aguiar1 Amilcar Tanuri1 Ana Plemenitas3 and B Matija Peterlin 2 Address 1Molecular Virology Laboratory Dep. of Genetics Federal University of Rio de Janeiro Rio de Janeiro Brazil 2Departments of Medicine Microbiology and Immunology Rosalind Russell Medical Research Center University of California at San Francisco San Francisco CA USA and institute of Biochemistry Faculty of Medicine University of Ljubljana Ljubljana Slovenia Email Luciana J Costa - ljcosta@biologia.ufrj.br Nan Chen - nan.chen@ucsf.edu Adriana Lopes - matija.peterlin@ucsf.edu Renato S Aguiar - matija.peterlin@ucsf.edu AmilcarTanuri - matija.peterlin@ucsf.edu Ana Plemenitas - ana.plemenitas@mf.uni-lj.si B Matija Peterlin - matija.peterlin@ucsf.edu Corresponding author tEqual contributors Published 09 June 2006 Received 05 May 2006 Retrovirology 2006 3 33 doi l0.ll86 l742-4690-3-33 Accepted 09 June 2006 This article is available from http www.retrovirology.cOm content 3 1 33 2006 Costa et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Nef is an accessory protein of primate lentiviruses HIV-1 HIV-2 and SIV. Besides removing CD4 and MHC class I from the surface and activating cellular signaling cascades Nef also binds GagPol during late stages of the viral replicative cycle. In this report we investigated further the ability of Nef to facilitate the replication of HIV-1. Results To this end first the release of new viral particles was much lower in the absence of Nef in a T cell line. Since the same results were obtained in the absence of .