Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "The discovery of the first human retrovirus: HTLV-1 and HTLV-2"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "The discovery of the first human retrovirus: HTLV-1 and HTLV-2. | Retrovirology BioMed Central Review Open Access The discovery of the first human retrovirus HTLV-1 and HTLV-2 Robert C Gallo 1 2 Address 1Institute of Human Virology University of Maryland Biotechnology Institute 725W Lombard Street Baltimore MD 21201 USA and 2Department of Microbiology and Immunology University of Maryland School of Medicine 655 W. Baltimore Street Baltimore MD 21201 USA Email Robert C Gallo - gallo@umbi.umd.edu Corresponding author Published 02 March 2005 Received 18 February 2005 Accepted 02 March 2005 Retrovirology 2005 2 17 doi 10.1186 1742-4690-2-17 H This article is available from http www.retrovirology.cOm content 2 1 17 2005 Gallo licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract I describe here the history leading up to and including my laboratory s discovery of the first human retrovirus HTLV-I and its close relative HTLV-II. My efforts were inspired by early work showing a retroviral etiology for leukemias in various animals including non-human primates. My two main approaches were to develop criteria for and methods for detection of viral reverse transcriptase and to identify growth factors that could support the growth of hematopoietic cells. These efforts finally yielded success following the discovery of IL-2 and its use to culture adult T cell lymphoma leukemia cells. Background After arriving at NIH in 1965 I spent my first year as a young physician caring and treating mostly unsuccessfully acute leukemias in children a vivid experience and one which made me absolute in a decision to be fully involved in laboratory research and not return to clinical medicine. My research interest almost from the very start was in the biology of blood cells and I focused on comparisons of human .