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Báo cáo y học: " Perception of urge-to-cough and dyspnea in healthy smokers with decreased cough reflex sensitivity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Perception of urge-to-cough and dyspnea in healthy smokers with decreased cough reflex sensitivity. | Kanezaki et al. Cough 2010 6 1 http www.coughjournal.eom content 6 1 1 RESEARCH w Cough Open Access Perception of urge-to-cough and dyspnea in healthy smokers with decreased cough reflex sensitivity Masashi Kanezaki1 Satoru Ebihara1 Etsuhiro Nikkuni1 Peijun Gui1 Chihiro Suda1 Takae Ebihara2 Miyako Yamasaki2 Masahiro Kohzuki1 Abstract Background Although cigarette smoking has been implicated as an important risk factor for the development of respiratory symptoms the perceptional aspects of two symptoms in smokers have not been fully elucidated. Therefore we simultaneously evaluated the cough reflex sensitivity the cognition of urge-to-cough and perception of dyspnea in both healthy smokers and non-smokers. Methods Fourteen male healthy never-smokers and 14 age-matched male healthy current-smokers were recruited via public postings. The cough reflex sensitivity and the urge-to-cough were evaluated by the inhalation of citric acid. The perception of dyspnea was evaluated by Borg scores during applications of external inspiratory resistive loads. Results The cough reflex threshold to citric acid as expressed by the lowest concentration of citric acid that elicited two or more coughs C2 and the lowest concentration of citric acid that elicited five or more coughs C5 in smokers was significantly higher than in non-smokers. The urge-to-cough log-log slope in smokers was significantly milder than that of non-smokers. There were no significant differences in the urge-to-cough threshold between non-smokers and smokers. There were no significant differences in perceptions of dyspnea between nonsmokers and smokers. Conclusions The study showed that decreased cough reflex sensitivity in healthy smokers was accompanied by a decreased cognition of urge-to-cough whereas it was not accompanied by the alternation of perception of dyspnea. Physicians should pay attention to the perceptual alterations of cough in smokers. Background Cough and dyspnea are common respiratory symptoms .