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Báo cáo y học: "validation of the ERS standard citric acid cough challenge in healthy adult volunteers"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: validation of the ERS standard citric acid cough challenge in healthy adult volunteers. | Wright et al. Cough 2010 6 8 http www.coughjournal.eom content 6 1 8 RESEARCH w Cough Open Access Validation of the ERS standard citric acid cough challenge in healthy adult volunteers Caroline E Wright Jennifer Jackson Rachel L Thompson Alyn H Morice Abstract Protocols measuring cough sensitivity can vary in terms of nebuliser tussive agent single and dose response. A definitive method for measuring cough sensitivity needs to be established. The ERS guidelines recommend the KoKo DigiDoser KD delivery system. Study aim was to compare the reproducibility of this citric acid CA cough challenge and previously established Mefar dosimeter MD protocol. 39 female 26 volunteers mean age 40.4 yrs were randomised to either KD or MD. Intra-day and inter-day reproducibility was compared. We calculated the concentration of citric acid evoking 2 coughs C2 . The geometric mean C2 95 CI was similar for both KD and MD of 263 200 339 mM and 209 151 288 mM respectively. The mean KD C2 was not significantly different. F 0.807 p 0.93 from baseline over 1 2 and 4 hrs however the MD demonstrated significant variability F 7.85 P 0.001 Measuring mean log C2 at baseline and at 2 weeks the KD demonstrated a stronger intraclass correlation of log C2 at baseline with 2 week log C2 ICC 0.70 than was shown with the Mefar ICC 0.41 Administering CA from KD offers a reproducible cough challenge in healthy volunteers. The results correlate well with the MD challenge but offer greater intra-day and inter-day reproducibility. Trial Registration Current controlled trials ISRCTN98385033 Background The methodology of citric acid cough challenge was first reported in humans over 50 yrs ago 1 . It was developed to allow for the quantification of cough reflex sensitivity and also as a tool for the assessment of antitussive therapies. Since this time many different protocols have been published and these can vary greatly in terms of the nebuliser used the tussive agent single breath single dose or dose .