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Báo cáo y học: " Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: treatment with the protease inhibitor, TL-3 | BioMed Central Retrovirology Research Open Access Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor TL-3 Sohela de Rozieres41 Christina H Swant2 Dennis A Sheeter2 Karen J Clingerman3 Ying-Chuan Lin1 Salvador Huitron-Resendiz4 Steven Henriksen4 Bruce E Torbett2 and John H Elder 1 Address Department of Molecular Biology The Scripps Research Institute La Jolla USA 2Department of Experimental Medicine The Scripps Research Institute La Jolla USA 3Department of Animal Resources The Scripps Research Institute La Jolla USA and 4Department of Neuropharmacology The Scripps Research Institute La Jolla CA 92037 USA Email Sohela de Rozieres - sohela@scripps.edu Christina H Swan - cswan@scripps.edu Dennis A Sheeter - dsheeter@scripps.edu Karen J Clingerman - karenc@scripps.edu Ying-Chuan Lin - ylin@scripps.edu Salvador Huitron-Resendiz - shuitron@scripps.edu Steven Henriksen - steven@scripps.edu Bruce E Torbett - betorbet@scripps.edu John H Elder - jelder@scripps.edu Corresponding author tEqual contributors Published 19 November 2004 Received 16 September 2004 Accepted 19 November 2004 Retrovirology 2004 1 38 doi l0.ll86 l742-4690-l-38 This article is available from http www.retrovirology.com content l l 38 2004 de Rozières et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The protease inhibitor TL-3 demonstrated broad efficacy in vitro against FIV HIV and SIV simian immunodeficiency virus and exhibited very strong protective effects on early neurologic alterations in the CNS of FIV-PPR infected cats. In this study we analyzed TL-3 efficacy using a highly pathogenic FIV-C isolate which causes a severe acute phase immunodeficiency syndrome with high early mortality rates.