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Báo cáo y học: "Another explanation for the low allergy rate in the rural Alpine foothills"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Another explanation for the low allergy rate in the rural Alpine foothills. | Clinical and Molecular Allergy BioMed Central Review Open Access Another explanation for the low allergy rate in the rural Alpine foothills Matthias Wjst Address Institut fur Epidemiologie GSF - Forschungszentrum fur Umwelt und Gesundheit Ingolstadter Landstrasse 1 D-85758 Neuherberg Munich Germany Email Matthias Wjst - m@wjst.de Corresponding author Published 05 June 2005 Received 25 January 2005 Clinical and Molecular Allergy 2005 3 7 doi l0.ll 86 1476-7961-3-7 Accepted 05 June 2005 This article is available from http www.clinicalmolecularallergy.cOm content 3 1 7 2005 Wjst licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A low allergy rate in coal and wood heated homes has been described in the small villages in the Alpine foothills and subsequently found to be associated with the farming environment. This was interpreted within the framework of the hygiene hypothesis but there are also alternative explanations. Lower air pollution could be one reason which is however unlikely since the differences between the Bavarian countryside and the Munich municipal area were only weak. There could be genetic differences between the urban and rural population by previous isolation or by self-selection. The potential drop-out of allergy genes however will also not explain the absent increase of allergies in two generations. More likely other lifestyle factors are important. Dietary habits are different in farmers and a less frequent vitamin D supplementation of newborns otherwise expected to be allergy promoting has been shown recently. The underlying cause for the non-allergic farm child remains speculative until the transfer of any farm-associated factor is leading to a similar risk reduction in the general population. .