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Báo cáo y học: "Evaluation of the sensitization rates and identification of IgE-binding components in wild and genetically modified potatoes in patients with allergic disorders"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evaluation of the sensitization rates and identification of IgE-binding components in wild and genetically modified potatoes in patients with allergic disorders. | Clinical and Molecular Allergy BioMed Central Research Evaluation of the sensitization rates and identification of Open Access IgE-binding components in wild and genetically modified potatoes in patients with allergic disorders Soo-Keol Lee1 Young-Min Ye2 Sung-Ho Yoon2 Bou-Oung Lee3 Seung- Hyun Kim2 and Hae-Sim Park 2 Address Department of Internal Medicine College of Medicine Dong-A University Busan 2Department of Allergy Rheumatology School of Medicine Ajou University Suwon and 3College of Agriculture Chonbuk National University Chonju Korea Email Soo-Keol Lee - skleeai@daunet.donga.ac.kr Young-Min Ye - ye9007@ajou.ac.kr Sung-Ho Yoon - ydfamill@naver.com Bou- Oung Lee - bolee@chonbuk.ac.kr Seung-Hyun Kim - shkim@ajou.ac.kr Hae-Sim Park - hspark@ajou.ac.kr Corresponding author Published 04 July 2006 Received 20 April 2006 Clinical and Molecular Allergy 2006 4 10 doi 10.1186 1476-7961-4-10 Accepted 04 July 2006 This article is available from http www.clinicalmolecularallergy.cOm content 4 1 10 2006 Lee et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The potato is one of the most common types of genetically modified GM food. However there are no published data evaluating the impact of genetic manipulations on the allergenicity of GM potatoes. To compare the allergenicity of GM potatoes with that of wild-type potatoes using in vivo and in vitro methods in adult allergy patients sensitized to potatoes. Methods A total of 1886 patients with various allergic diseases and 38 healthy controls participated in the study. Skin-prick testing and IgE-ELISA were carried out with extracts prepared from wild-type and GM potatoes. An ELISA inhibition test was used to confirm the binding specificity. IgE-binding .