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Báo cáo y học: "Effects of interventional lung assist on haemodynamics and gas exchange in cardiopulmonary resuscitation: a prospective experimental study on animals with acute respiratory distress syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of interventional lung assist on haemodynamics and gas exchange in cardiopulmonary resuscitation: a prospective experimental study on animals with acute respiratory distress syndrome. | Available online http ccforum.eom content 13 1 R17 Open Access Research Effects of interventional lung assist on haemodynamics and gas exchange in cardiopulmonary resuscitation a prospective experimental study on animals with acute respiratory distress syndrome Gunther Zick Dirk Schadler Gunnar Elke Sven Pulletz Berthold Bein Jens Scholz Inez Frerichs and Norbert Weiler Department of Anesthesiology and Intensive Care Medicine University Medical Center Schleswig-Holstein Campus Kiel Arnold-Heller-StraBe 3 D24105 Kiel Germany Corresponding author Gunther Zick zick@anaesthesie.uni-kiel.de Received 19 Sep 2008 Revisions requested 27 Sep 2008 Revisions received 20 Jan 2009 Accepted 11 Feb 2009 Published 11 Feb 2009 Critical Care 2009 13 R17 doi 10.1186 cc7716 This article is online at http ccforum.com content 13 1 R1 7 2009 Zick et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Interventional lung assist ILA based on the use of a pumpless extracorporeal membrane oxygenator facilitates carbon dioxide CO2 elimination in acute respiratory distress syndrome ARDS . It is unclear whether an ILA system should be clamped during cardiopulmonary resuscitation CPR in patients with ARDS or not. The aim of our study was to test the effects of an ILA on haemodynamics and gas exchange during CPR on animals with ARDS and to establish whether the ILA should be kept open or clamped under these circumstances. Methods The study was designed to be prospective and experimental. The experiments were performed on 12 anaesthetised and mechanically ventilated pigs weighing 41 to 58 kg . One femoral artery and one femoral vein were cannulated and connected to an ILA. ARDS was induced by repeated bronchoalveolar lavage. An .