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Báo cáo y học: "Homeostatic mechanisms in dopamine synthesis and release: a mathematical model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. | Theoretical Biology and Medical Modelling BioMed Central Research Homeostatic mechanisms in dopamine synthesis and release a mathematical model Janet A Best f1 H Frederik Nijhoutt2 and Michael C Reedt3 Open Access Address Department of Mathematics The Ohio State University Columbus OH 43210 USA 2Department of Biology Duke University Durham NC 27708 USA and 3Department of Mathematics Duke University Durham NC 27708 USA Email Janet A Best - jbest@math.ohio-state.edu H Frederik Nijhout - hfn@duke.edu Michael C Reed - reed@math.duke.edu Corresponding author tEqual contributors Published 10 September 2009 Received 23 April 2009 Theoretical Biology and Medical Modelling 2009 6 21 doi 10.1186 1742-4682-6-21 Accepted 10 September 2009 This article is available from http www.tbiomed.cOm content 6 1 21 2009 Best et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Dopamine is a catecholamine that is used as a neurotransmitter both in the periphery and in the central nervous system. Dysfunction in various dopaminergic systems is known to be associated with various disorders including schizophrenia Parkinson s disease and Tourette s syndrome. Furthermore microdialysis studies have shown that addictive drugs increase extracellular dopamine and brain imaging has shown a correlation between euphoria and psychostimulant-induced increases in extracellular dopamine 1 . These consequences of dopamine dysfunction indicate the importance of maintaining dopamine functionality through homeostatic mechanisms that have been attributed to the delicate balance between synthesis storage release metabolism and reuptake. Methods We construct a .