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Báo cáo y học: " Proof-of-principle investigation of an algorithmic model of adenosine-mediated angiogenesis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Proof-of-principle investigation of an algorithmic model of adenosine-mediated angiogenesis. | Azuaje et al. Theoretical Biology and Medical Modelling 2011 8 7 http www.tbiomed.eom content 8 1 7 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access Proof-of-principle investigation of an algorithmic model of adenosine-mediated angiogenesis - A 1 1 1 w P s 1 1.2 Francisco Azuaje Frédérique Leonard Magali Rolland-Turner Yvan Devaux and Daniel R Wagner Correspondence Francisco. Azuaje@crp-sante.lu laboratory of Cardiovascular Research Centre de Recherche Public - Santé CRP-Santé L-1150 Luxembourg Luxembourg Full list of author information is available at the end of the article 2 BioMed Central Abstract Background We investigated an algorithmic approach to modelling angiogenesis controlled by vascular endothelial growth factor VEGF the anti-angiogenic soluble VEGF receptor 1 sVEGFR-1 and adenosine Ado . We explored its feasibility to test angiogenesis-relevant hypotheses. We illustrated its potential to investigate the role of Ado as an angiogenesis modulator by enhancing VEGF activity and antagonizing sVEGFR-1. Results We implemented an algorithmic model of angiogenesis consisting of the dynamic interaction of endothelial cells VEGF sVEGFR-1 and Ado entities. The model is based on a logic rule-based methodology in which the local behaviour of the cells and molecules is encoded using if-then rules. The model shows how Ado may enhance angiogenesis through activating and inhibiting effects on VEGF and sVEGFR-1 respectively. Despite the relative simplicity of the model it recapitulated basic features observed in in vitro models. However observed disagreements between our models and in vitro data suggest possible knowledge gaps and may guide future experimental directions. Conclusions The proposed model can support the exploration of hypotheses about the role of different molecular entities and experimental conditions in angiogenesis. Future expansions can also be applied to assist research planning in this and other biomedical domains. Background .