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Báo cáo y học: " The function of 7D-cadherins: a mathematical model predicts physiological importance for water transport through simple epithelia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " The function of 7D-cadherins: a mathematical model predicts physiological importance for water transport through simple epithelia | Ahl et al. Theoretical Biology and Medical Modelling 2011 8 18 http www.tbiomed.eom content 8 1 18 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access The function of 7D-cadherins a mathematical model predicts physiological importance for water transport through simple epithelia Mareike Ahl1 2 Agnes Weth1 Sebastian Walcher3 and Werner Baumgartner1 Correspondence werner@bio2. rwth-aachen.de department of Cellular Neurobionics Institute of Zoology RWTH-Aachen University Aachen Germany Full list of author information is available at the end of the article 2 BioMed Central Abstract Background 7D-cadherins like LI-cadherin are cell adhesion molecules and represent exceptional members of the cadherin superfamily. Although LI-cadherin was shown to act as a functional Ca2 -dependent adhesion molecule linking neighboring cells together and to be dysregulated in a variety of diseases the physiological role is still enigmatic. Interestingly 7D-cadherins occur only in the lateral plasma membranes of cells from epithelia of water transporting tissues like the gut the liver or the kidney. Furthermore LI-cadherin was shown to exhibit a highly cooperative Ca2 -dependency of the binding activity. Thus it is tempting to assume that LI-cadherin regulates the water transport through the epithelium in a passive fashion by changing its binding activity in dependence on the extracellular Ca2 . Results We developed a simple mathematical model describing the epithelial lining of a lumen with a content of variable osmolarity covering an interstitium of constant osmolarity. The width of the lateral intercellular cleft was found to influence the water transport significantly. In the case of hypertonic luminal content a narrow cleft is necessary to further increase concentration of the luminal content. If the cleft is too wide the water flux will change direction and water is transported into the lumen. Electron microscopic images show that in fact areas of the gut can be found .