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Báo cáo y học: "Impaired glucose and nutrient absorption in critical illness: is gastric emptying only a piece of the puzzle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Impaired glucose and nutrient absorption in critical illness: is gastric emptying only a piece of the puzzle? | Available online http ccforum.eom content 13 5 190 Commentary Impaired glucose and nutrient absorption in critical illness is gastric emptying only a piece of the puzzle Alain Dive Department of Intensive Care Louvain School of Medicine Mont-Godinne Hospital 5530 Yvoir Belgium Corresponding author A Dive alain-michel.dive@uclouvain.be Published 1 October 2009 This article is online at http ccforum.com content 13 5 190 2009 BioMed Central Ltd Critical Care 2009 13 190 doi 10.1186 cc8049 See related research by Chapman et al. http ccforum.com content 13 4 R140 Abstract This commentary highlights the contribution of the article by Chapman and colleagues assessing the relationships between glucose absorption glycaemia and gastric emptying during critical illness. In addition to several more expected findings their data suggest that factors other than slow gastric emptying may limit glucose absorption during critical illness. This hypothesis has received little attention so far although numerous small intestinal abnormalities possibly interfering with absorption are known to occur in intensive care patients. Future work should focus on further validation of tools to assess nutrient absorption in the critically ill before defining the precise causes and mechanisms that are involved. In a recent issue of Critical Care Chapman and colleagues 1 report a study aiming to quantify glucose absorption and the relationships between gastric emptying glucose absorption and glycaemia in critically ill patients. This study follows many publications from the same Australian group that have contributed greatly to better our understanding of gastrointestinal failure during critical illness 2 . They analysed the kinetics of glucose absorption glycaemia modifications and gastric emptying after a test meal in 19 critically ill patients with comparison to healthy volunteers. The test meal was administered by nasogastric bolus however a modality of administration somewhat different from the