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Báo cáo y học: " A plethora of angiopoietin-2 effects during clinical sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A plethora of angiopoietin-2 effects during clinical sepsis. | van Nieuw Amerongen and Groeneveld Critical Care 2010 14 166 http ccforum.eom content 14 3 166 CRITICAL CARE COMMENTARY L__ A plethora of angiopoietin-2 effects during clinical sepsis Geerten P van Nieuw Amerongen1 and AB Johan Groeneveld2 See related research by Davis etal. http ccforum.Com content 14 3 R89 Abstract The interesting study by Davis and colleagues in the current issue of Critical Care expands on the increasingly recognized role of angiopoietins in human sepsis but raises a number of questions which are discussed in this commentary. The authors describe an association between elevated angiopoietin ang -2 levels and impaired vascular reactivity measured by the partly nitric oxide-dependent finger hyperemic response to forearm vascular occlusion in patients with sepsis. This suggests that the ang-1 2-Tie2 system is involved in a number of pathophysiologic phenotypic and perhaps prognostic alterations in human sepsis on top of the effect on pulmonary endothelial barrier function. The novel inflammatory route may be a target for future therapeutic studies in human sepsis and acute lung injury including those with activated protein C. In the past decade the angiopoietin ang -1 2-Tie2 system has increasingly been suggested to play a major role in the various features of human sepsis and acute lung injury and has thereby been considered as a novel therapeutic target 1-3 . High circulating ang-2 levels promote inflammation and vascular permeability in the lungs while ang-1 has a protective effect and these associations are confirmed by clinical studies 4 5 . The putative role of the ang-2 1 balance is gradually being expanded by studies showing that ang-2 levels may predict acute kidney injury and ICU outcome even independently of disease severity 4 6 . In the current issue of Critical Care Davis and colleagues 1 provide additional evidence that ang-2 release is Correspondence johan.groeneveld@vumc.nl department of Physiology Institute for .