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Báo cáo y học: "Could a simple surgical intervention eliminate HIV infection?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Could a simple surgical intervention eliminate HIV infection? | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Could a simple surgical intervention eliminate HIV infection Slobodan Tepic Address School of Veterinary Medicine University of Zurich Zurich Switzerland Email Slobodan Tepic - kyon@datacomm.ch Corresponding author Published 31 August 2004 Received 03 August 2004 Theoretical Biology and Medical Modelling 2004 1 7 doi 10.1186 1742-4682-1-7 AccePted 31 August 2004 This article is available from http www.tbiomed.cOm content 1 1 7 2004 Tepic licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human Immunodeficiency Virus HIV infection is a dynamic interaction of the pathogen and the host uniquely defined by the preference of the pathogen for a major component of the immune defense of the host. Simple mathematical models of these interactions show that one of the possible outcomes is a chronic infection and much of the modelling work has focused on this state. Bifurcation However the models also predict the existence of a virus-free equilibrium. Which one of the equilibrium states the system selects depends on its parameters. One of these is the net extinction rate of the preferred HIV target the CD4 lymphocyte. The theory predicts somewhat counterintuitively that above a critical extinction rate the host could eliminate the virus. The question then is how to increase the extinction rate of lymphocytes over a period of several weeks to several months without affecting other parameters of the system. Testing the hypothesis Proposed here is the use of drainage or filtration of the thoracic duct lymph a well-established surgical technique developed as an alternative for drug immunosuppression for organ transplantation. The performance of .