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Báo cáo y học: " Size control in growing yeast and mammalian cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Size control in growing yeast and mammalian cells | Theoretical Biology and Medical Modelling BioMed Central Commentary Size control in growing yeast and mammalian cells Akos Sveiczer 1 Bela Novak1 2 and J Murdoch Mitchison3 Open Access Address Department of Agricultural Chemical Technology Budapest University of Technology and Economics 1111 Budapest Szt. Gellert ter 4 Hungary 2Molecular Network Dynamics Research Group of Hungarian Academy of Sciences Budapest University of Technology and Economics 1111 Budapest Szt. Gellert ter 4 Hungary and institute of Cell Animal and Population Biology University of Edinburgh Ashworth Laboratories West Mains Rd Edinburgh EH9 3JT Scotland UK Email Akos Sveiczer - asveiczer@mail.bme.hu Bela Novak - bnovak@mail.bme.hu J Murdoch Mitchison - j.m.mitchison@ed.ac.uk Corresponding author Published 16 November 2004 Received 20 September 2004 Theoretical Biology and Medical Modelling 2004 1 12 doi l0.ll86 l742-4682-l-l2 Accepted 16 November 2004 This article is available from http www.tbiomed.eom content l l l2 2004 Sveiczer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In a recent publication it was claimed that cultured mammalian cells in contrast to yeasts maintain a constant size distribution in the population without a size checkpoint. This inference may be challengeable. Results l It is argued that weak size control implies the existence of a checkpoint and unfortunately the technique used by Conlon and Raff might obscure such a weak mechanism. 2 Previous investigations of size control in yeasts have shown that individual cell data rather than means and variances of cell populations are prerequisites for reliable interpretation. 3 No experimental data so far obtained suggest that in any cell culture a linear .