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Báo cáo y học: "Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b | BioMed Central Theoretical Biology and Medical Modelling Research Open Access Common angiotensin receptor blockers may directly modulate the immune system via VDR PPAR and CCR2b Trevor G Marshall 1 Robert E Lee2 and Frances E Marshall3 Address 1Autoimmunity Research Foundation Thousand Oaks California 91360 USA 2Black Hawk College Moline Illinois 61443 USA and 3Los Robles Regional Medical Centre Thousand Oaks California 91360 USA Email Trevor G Marshall - trevor.m@AutoimmunityResearch.org Robert E Lee - leeb@bhc.edu Frances E Marshall - liz.m@yarcrip.com Corresponding author Published 10 January 2006 Received 07 December 2005 Theoretical Biology and Medical Modelling 2006 3 1 doi 10.1186 1742-4682-3-1 Accepted I0 January 2006 This article is available from http www.tbiomed.cOm content 3 1 1 2006 Marshall et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background There have been indications that common Angiotensin Receptor Blockers ARBs may be exerting anti-inflammatory actions by directly modulating the immune system. We decided to use molecular modelling to rapidly assess which of the potential targets might justify the expense of detailed laboratory validation. We first studied the VDR nuclear receptor which is activated by the secosteroid hormone 1 25-dihydroxyvitamin-D. This receptor mediates the expression of regulators as ubiquitous as GnRH Gonadatrophin hormone releasing hormone and the Parathyroid Hormone PTH . Additionally we examined Peroxisome Proliferator-Activated Receptor Gamma PPARgamma which affects the function of phagocytic cells and the C-CChemokine Receptor type 2b CCR2b which recruits monocytes to the site of inflammatory immune challenge. Results Telmisartan was predicted to strongly .

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