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Báo cáo y học: " Redox-mediated bypass of restriction point via skipping of G1pm"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Redox-mediated bypass of restriction point via skipping of G1pm | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Redox-mediated bypass of restriction point via skipping of Glpm Arnold Hoffman1 James J Greene2 Lee M Spetner1 and Michael Burke 1 3 Address 1Redoxia Jerusalem Israel 2Catholic University of America Washington DC USA and 3Tel Aviv Sourasky Medical Center Tel Aviv Israel Email Arnold Hoffman - hofarnold@gmail.com James J Greene - greene@cua.edu Lee M Spetner - lspetner@alum.mit.edu Michael Burke - drmburke@yahoo.com Corresponding author Published 25 July 2006 Received 26 February 2006 Theoretical Biology and Medical Modelling 2006 3 26 doi 10.1186 1742-4682-3-26 Accepted 25 July 2006 This article is available from http www.tbiomed.eom content 3 1 26 2006 Hoffman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It is well known that cancer cells bypass the restriction point R and undergo uncontrolled cell proliferation. Hypothesis and evidence We suggest here that fibrosarcoma cells enter G1ps directly from M skipping G1pm hence bypassing R in response to redox modulation. Evidence is presented from the published literature that demonstrate a shortening of the cycle period of transformed fibroblasts SV-3T3 compared to the nontransformed 3T3 fibroblasts corresponding to the duration of G1pm in the 3T3 fibroblasts. Evidence is also presented that demonstrate that redox modulation can induce the CUA-4 fibroblasts to bypass R resulting in a cycle period closely corresponding to the cycle period of fibrosarcoma cells HTI080 . Conclusion The evidence supports our hypothesis that a low internal redox potential can cause fibrosarcoma cells to skip the G1pm phase of the cell cycle. Background The normal cell cycle consists of four .