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Báo cáo y học: "Propagation velocity profile in a cross-section of a cardiac muscle bundle from PSpice simulation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Propagation velocity profile in a cross-section of a cardiac muscle bundle from PSpice simulation | Theoretical Biology and Medical Modelling BioMed Central Research Propagation velocity profile in a cross-section of a cardiac muscle bundle from PSpice simulation Nicholas Sperelakis1 and Lakshminarayanan Ramasamy 2 Open Access Address Dept. of Molecular Cellular Physiology University of Cincinnati College of Medicine Cincinnati OH 45267-0576 USA and 2Dept. of Electrical Computer Engineering and Computer Science University of Cincinnati College of Engineering Cincinnati OH 45219 USA Email Nicholas Sperelakis - spereln@ucmail.uc.edu Lakshminarayanan Ramasamy - lakshmr@ececs.uc.edu Corresponding author Published 15 August 2006 Received 26 June 2006 Theoretical Biology and Medical Modelling 2006 3 29 doi 10.1186 1742-4682-3-29 Accepted 15 August 2006 This article is available from http www.tbiomed.cOm content 3 1 29 2006 Sperelakis and Ramasamy licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The effect of depth on propagation velocity within a bundle of cardiac muscle fibers is likely to be an important factor in the genesis of some heart arrhythmias. Model and methods The velocity profile of simulated action potentials propagated down a bundle of parallel cardiac muscle fibers was examined in a cross-section of the bundle using a PSpice model. The model 20 X 10 consisted of 20 chains in parallel each chain being 10 cells in length. All 20 chains were stimulated simultaneously at the left end of the bundle using rectangular current pulses 0.25 nA 0.25 ms duration applied intracellularly. The simulated bundle was symmetrical at the top and bottom including two grounds and voltage markers were placed intracellularly only