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Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley? | Soreide Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2011 19 28 http www.sjtrem.eom content 19 1 28 SCANDINAVIAN JOURNAL OF Et emergency medicine EDITORIAL Open Access The role of high-mobility group box-1 HMGB-1 in the management of suspected acute appendicitis useful diagnostic biomarker or just another blind alley Kjetil S0reide Abstract Acute abdominal pain is one of the most frequent reasons for admitting patients to the emergency department for surgical evaluation. A wide number of differential diagnoses are available and their pre-test likelihood ratio varies according to the patients age gender duration of symptoms and overall clinical context. While many patients with abdominal pain do not need to be admitted to the hospital wards and even fewer need eventual surgical intervention the diagnosis of acute appendicitis remains one of the most frequently entertained differential in patients with abdominal pain. In fact surgery for appendicitis is one of the most frequently performed operations in the Western world. As the authors of the current study point out the high mobility group box-1 protein HMGB1 has been known for many years. The study demonstrates in a small pilot that there is a difference in expression of HMGB1 between those with and those without appendicitis. However is this difference clinically important Clinically relevant results can only be documented through larger studies comparing its use and expression levels in both healthy subjects subjects with abdominal pain for other reasons patients with clearcut histopathologically confirmed appendicitis and in the difficult subgroup of patients with suspected appendicitis and equivocal symptoms. Acute abdominal pain is one of the most frequent reasons for admitting patients to the emergency department for surgical evaluation. A wide number of differential diagnoses are available and their pre-test likelihood ratio varies according to the patients age gender duration of .