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Báo cáo y học: "High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome. | Guervilly et al. Critical Care 2011 15 R31 http ccforum.eom content 15 1 R31 KS CRITICAL CARE RESEARCH Open Access High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome 1 2 1 1 2 Christophe Guervilly Romaric Lacroix Jean-Marie Forel Antoine Roch Laurence Camoin-Jau Laurent Papazian 1 Franpoise Dignat-George2 Abstract Introduction The current study has addressed the presence and the cellular origin of microparticles MP isolated from bronchoalveolar lavage BAL fluid and from blood samples from patients with acute respiratory distress syndrome ARDS . Their prognostic interest was also investigated. Methods Fifty-two patients were included within the first 24 hours of ARDS. They were compared to spontaneous breathing SB and ventilated control VC groups. Bronchoalveolar lavage BAL and blood samples were obtained on Day 1 and Day 3 in an ARDS group. Leukocyte microparticles LeuMP neutrophil microparticles NeuMP endothelial microparticles EMP and platelet microparticles PMP were measured in arterial blood and in BAL samples by flow cytometry. Mortality from all causes was recorded at Day 28. Results All MP subpopulations were detected in BAL. However only LeuMP and NeuMP were elevated in ARDS patients compared to the SB group P 0.002 for both . Among ARDS patients higher levels of LeuMP were detected in blood Day 1 and in BAL Day 3 in survivors as compared with the non survivors. Circulating LeuMP 60 elements microliter detectable on Day 1 of ARDS was associated with a higher survival rate odds ratio 5.26 95 confidence interval 1.10 to 24.99 P 0.037 . Conclusions The identification of the cellular origin of microparticles at the onset of ARDS has identified LeuMP as a biomarker of prognostic significance. The higher levels of LeuMP in survivors could be associated with a protective role of this MP subpopulation. This hypothesis needs further investigations. Introduction Acute Lung Injury ALI and its .