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Báo cáo y học: " Human-macaque comparisons illuminate variation in neutral substitution rates"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Human-macaque comparisons illuminate variation in neutral substitution rates. | Open Access Human-macaque comparisons illuminate variation in neutral substitution rates Svitlana Tyekucheva Ý Kateryna D Makova John E Karro Ross C Hardison Webb Miller t and Francesca Chiaromonte Addresses Center for Comparative Genomics and Bioinformatics The Pennsylvania State University University Park PA 16802 USA. Department of Statistics The Pennsylvania State University University Park PA 16802 USA. Department of Biology The Pennsylvania State University University Park PA 16802 USA. Department of Computer Science and System Analysis Miami University Oxford OH 45056 USA. Department of Microbiology Miami University Oxford OH 45056 USA. Department of Biochemistry and Molecular Biology The Pennsylvania State University University Park PA 16802 USA. Department of Computer Science and Engineering The Pennsylvania State University University Park PA 16802 USA. Correspondence Francesca Chiaromonte. Email chiaro@stat.psu.edu Published 30 April 2008 Genome Biology 2008 9 R76 doi 10.1 186 gb-2008-9-4-r76 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 4 R76 Received 10 January 2008 Revised 4 April 2008 Accepted 30 April 2008 2008 Tyekucheva et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The evolutionary distance between human and macaque is particularly attractive for investigating local variation in neutral substitution rates because substitutions can be inferred more reliably than in comparisons with rodents and are less influenced by the effects of current and ancient diversity than in comparisons with closer primates. Here we investigate the humanmacaque neutral substitution rate as a function of a number of genomic .