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Báo cáo sinh học: "Haplotype diversity of the myostatin gene among beef cattle breeds"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Haplotype diversity of the myostatin gene among beef cattle breeds | 103 Genet Sei. Evol. 35 2003 103-118 INRA EDP Sciences 2003 DOI 10.1051 gse 2002038 Original article Haplotype diversity of the myostatin gene among beef cattle breeds Susana Dunnera M. Eugenia Mirandaa Yves Amiguesb Javier Canona Michel Georgesc Roger Hansetd John Williams Francois MẺNissiERf a Laboratorio de genética molecular Facultad de Veterinaria Universidad Complutense de Madrid 28040 Madrid Spain B Labogena 78352 Jouy-en-Josas Cedex France c Department of genetics Faculty of Veterinary Medicine University of Liège B43 20 Bd de Colonster 4000 Liège Belgium d Herdbook BBB 4 rue Champs Elysées 5590 Ciney Belgium E Roslin Institute EH25 9PS Midlothian UK f Institut national de la recherche agronomique Station de génétique quantitative et appliquée Domaine de Vilvert 78352 Jouy-en-Josas Cedex France Received 11 January 2002 accepted 2 August 2002 Abstract - a total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism SSCP method. Seven new mutations were identified which contribute to the high polymorphism 1 SNP every 100 bp present in this small gene twenty haplotypes were described and a genotyping method was set up using the Oligonucleotide Ligation Assay OLA method. Some haplotypes appeared to be exclusive to a particular breed this was the case for 5 in the Charolaise involving mutation Q204X and 7 in the Maine-Anjou involving mutation E226X . The relationships between the different haplotypes were studied thus allowing to test the earlier hypothesis on the origin of muscular hypertrophy in Europe muscular hypertrophy namely nt821 del11 was mainly spread in different waves from northern Europe milk purpose populations in most breeds however other mutations mostly disruptive arose in a single breed were highly selected and have since scarcely evolved to other populations. muscular hypertrophy myostatin gene haplotype diversity beef cattle breeds 1. .