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Báo cáo y học: "Transcription regulation: no holy grail, but many treasures"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Transcription regulation: no holy grail, but many treasures. | Meeting report Transcription regulation no holy grail but many treasures Nicola A Hawkes and Patrick Varga-Weisz Address Babraham Institute Babraham Cambridge CB3 4AT UK. Correspondence Patrick Varga-Weisz. E-mail patrick.varga-weisz@bbsrc.ac.uk Published 29 June 2005 Genome Biology 2005 6 334 doi l0.ll86 gb-2005-6-7-334 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 7 334 2005 BioMed Central Ltd A report of the Biochemical Society Annual Symposium Transcription UK London UK 13-15 April 2005. How does a transcription factor bring about gene regulation This key question has been tackled for decades but there is no unifying answer. Some researchers emphasize recruitment mechanisms by which activators target the basal machinery in effect RNA polymerase to the promoter and some put the emphasis on regulation through alterations in chromatin structure and histone modifications. A recent meeting on transcription in London provided an opportunity to learn about progress in this field. Focus on RNA polymerase In a meeting on transcription a surprising statement by Peter Cook University of Oxford UK was that transcription does not happen very often. But this is what his analysis of transcript abundance in Escherichia coli and yeast suggests. Even when RNA polymerase has been recruited to a promoter only a small minority of the transcripts initiated will make it to full-length RNA as the processes of initiation elongation and termination are subject to multiple levels of regulation as described in several other talks at the meeting. The take-home message given by Jesper Svejstrup Cancer Research UK London UK may be just as paradoxical as Cook s namely that RNA polymerase II pol II degradation can be good for transcription. This is because stalled pol II could be fatal. A DNA strand break can lead to pol II arrest and as RNA polymerase cannot bypass the lesion the stalled pol II will lead to a pile-up of .