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Báo cáo y học: " Epigenetic regulation: DNA confers identity but is not enough to maintain it"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Epigenetic regulation: DNA confers identity but is not enough to maintain it. | Meeting report Epigenetic regulation DNA confers identity but is not enough to maintain it Raymond A Poot and Richard Festenstein Addresses MRC Clinical Sciences Centre Faculty of Medicine Imperial College Hammersmith Campus Du Cane Road London W12 0NN UK. Department of Cell Biology Erasmus University Medical Centre Dr Molewaterplein 50 3015 GE Rotterdam The Netherlands. Correspondence Raymond Poot. Email r.poot@erasmusmc.nl. Richard Festenstein. Email r.festenstein@imperial.ac.uk Published 27 January 2006 Genome Biology 2006 7 302 doi l0.ll86 gb-2006-7-l-302 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 1 302 2006 BioMed Central Ltd A report on the conference Epigenetics and the dynamic genome 30 June-2 July 2005 Babraham Cambridge UK. For a cell to remember its identity and its goal in life takes more than genetic information in the form of DNA. On and off states of genes have to be preserved sometimes over generations. This is done by a set of mechanisms that are often called epigenetic as they are not encoded by the genome. A meeting on Epigenetics and the dynamic genome at the Babraham Institute in the countryside outside Cambridge was an opportunity to hear the latest progress in this fastmoving field. New players in epigenetic regulation Understanding the full spectrum of histone modifications and their effects on gene regulation is central to understanding epigenetics. Tony Kouzarides University of Cambridge UK opened the meeting by revealing a new histone-modify-ing enzyme in budding yeast. The yeast protein Fpr4 can isomerize proline 38 in histone H3 which has the effect of inhibiting the methylation of lysine 36 on histone H3 H3 K36 . Yang Shi Harvard Medical School Boston USA updated us on lysine-specific histone demethylase 1 LSD1 a histone H3 K4 demethylase. He reported that the cofactor for the repressor element 1 silencing transcription factor coREST binds LSD1 and is essential .