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Báo cáo y học: "Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila. | Research Open Access Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila Yongsheng Bai Claudio Casola Cédric Feschotte and Esther Betrán Address Department of Biology University of Texas at Arlington Arlington TX 76019 USA. Correspondence Esther Betrán. Email betran@uta.edu Published 18 January 2007 Genome Biology 2007 8 R1 I doi 10.1 l86 gb-2007-8-l-rll The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 1 R11 Received 7 September 2006 Revised 13 November 2006 Accepted l8 January 2007 2007 Bai et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Processed copies of genes retrogenes are duplicate genes that originated through the reverse-transcription of a host transcript and insertion in the genome. This type of gene duplication as any other could be a source of new genes and functions. Using whole genome sequence data for 12 Drosophila species we dated the origin of 94 retroposition events that gave rise to candidate functional genes in D. melanogaster. Results Based on this analysis we infer that functional retrogenes have emerged at a fairly constant rate of 0.5 genes per million years per lineage over the last approximately 63 million years of Drosophila evolution. The number of functional retrogenes and the rate at which they are recruited in the D. melanogaster lineage are of the same order of magnitude as those estimated in the human lineage despite the higher deletion bias in the Drosophila genome. However unlike primates the rate of retroposition in Drosophila seems to be fairly constant and no burst of retroposition can be inferred from our analyses. In .