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Báo cáo sinh học: " Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC | Genetic Vaccines and Therapy BioMed Central Research Open Access Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC Oliver Ebert1 3 Dorothee Wilbert1 Peter Buttgereit1 Carsten Ziske1 Dimitri Flieger2 and Ingo GH Schmidt-Wolf 1 Address 1Medizinische Klinik und Poliklinik I Rheinische Friedrich-Wilhelms-Universitat Bonn Germany 2Medizinische Klinik II Klinikum Aschaffenburg Germany and 3Department of Gene and Cell Medicine Mount Sinai School of Medicine New York New York USA Email Oliver Ebert - oliver.ebert@mssm.edu Dorothee Wilbert - picasso@uni-bonn.de Peter Buttgereit - peter.buttgereit@amaxa.com CarstenZiske - ziske@uni-bonn.de Dimitri Flieger - D.Flieger@uni-bonn.de Ingo GH Schmidt-Wolf - Ingo.Schmidt-Wolf@ukb.uni-bonn.de Corresponding author Published 14 October 2004 Received 28 June 2004 Accepted 14 October 2004 Genetic Vaccines and Therapy 2004 2 15 doi 10.1186 1479-0556-2-15 H This article is available from http www.gvt-journal.com content 2 1 15 2004 Ebert et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Modulation of the immune system by genetically modified lymphoma cell vaccines is of potential therapeutic value in the treatment of B cell lymphoma. However the anti-tumor effect of any single immunogene transfer has so far been limited. Combination treatment of recombinant IL-2 and IL-12 has been reported to be synergistic for inducing anti-tumor responses in solid tumors but the potential of IL-2 IL-12 gene modified B cell lymphoma cells has not been explored yet. Methods Using three different human B cell lymphoma cell lines and primary samples from patients with B cell neoplasms expression levels of the coxsackie .