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Báo cáo y học: " Recombination and base composition: the case of the highly self-fertilizing plant Arabidopsis thaliana"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Recombination and base composition: the case of the highly self-fertilizing plant Arabidopsis thaliana. | Research Open Access Recombination and base composition the case of the highly self-fertilizing plant Arabidopsis thaliana G Marais B Charlesworth and SI Wright Addresses institute of Cell Animal and Population Biology University of Edinburgh EH9 3JT Edinburgh UK. Current address Department of Biology York University 4700 Keele St Toronto Ontario M3J 1P3 Canada. Correspondence SI Wright. E-mail stephenw@yorku.ca Published 14 June 2004 Genome Biology 2004 5 R45 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 5 7 R45 Received 26 March 2004 Revised 26 April 2004 Accepted 30 April 2004 2004 Marais et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Rates of recombination can vary among genomic regions in eukaryotes and this is believed to have major effects on their genome organization in terms of base composition DNA repeat density intron size evolutionary rates and gene order. In highly self-fertilizing species such as Arabidopsis thaliana however heterozygosity is expected to be strongly reduced and recombination will be much less effective so that its influence on genome organization should be greatly reduced. Results Here we investigated theoretically the joint effects of recombination and self-fertilization on base composition and tested the predictions with genomic data from the complete A. thaliana genome. We show that in this species both codon-usage bias and GC content do not correlate with the local rates of crossing over in agreement with our theoretical results. Conclusions We conclude that levels of inbreeding modulate the effect of recombination on base composition and possibly other genomic features for example transposable element dynamics . We argue that inbreeding should be considered .