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báo cáo khoa học: "changes of the homologues possible cause of abnormal disjunction in female mice heterozygous for Robertsonian translocations"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: changes of the homologues possible cause of abnormal disjunction in female mice heterozygous for Robertsonian translocations | Génét. Sél. Evol. 1988 20 3 299-306 Structural changes of the homologues as a possible cause of abnormal disjunction in female mice heterozygous for Robertsonian translocations A.o. RUVINSKY S.I. AGULNIK A.I. AGULNIK and D.K. BELYAEV Institute of Cytology and Genetics Academy of Sciences of the USSR Siberian Division Novosibirsk-90 USSR Summary Mutations T Fu and Ahaplotype on chromosome 17 cause preferential transmission of the acrocentric homologues in the progeny of female mice heterozygotes for Robertsonian translocations Rb . The present results demonstrate that the influence of these mutations upon segregation is restricted to the Robertsonian translocations involving chromosome 17. Substitution of parts of chromosome 17 distal or proximal to the T locus did not alter the effect of this chromosome on the transmission rate of the homologue. The effects of these mutations whether cis or trans with Rb on the transmission were the same. It was established that Rbl3LubCLubl tf females reveal significant segregation distortion. However in the progeny of Rbl3LubtwLub I f females chromosome segregation did not differ from that theoretically expected. Rb7 T43H mothers transmitted the chromosome with the reciprocal translocation T43H to 70.9 of their progeny. Thus data were obtained supporting the idea that structural changes of the chromosomes caused by mutations affect the segregation of the homologues in Rb heterozygous females. Key words mice Robertsonian translocation chromosome segregation. Resume Modifications de la structure des chromosomes homologues une cause possible de la disjonction anormale chez les souris femelies heterozygotes pour des translocations robertsoniennes La presence des mutations T Fu OU du haplotype t6 sur le chromosome 17 entraine une transmission preferentielle des chromosomes homologues acrocentriques aux produits de souris femelles heterozygotes pour des translocations robertsoniennes Rb . Les résultats présentés dans cet article .