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Báo cáo y học: "Sequence and structure of Brassica rapa chromosome A3."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Sequence and structure of Brassica rapa chromosome A3. | Mun et al. Genome Biology 2010 11 R94 http genomebiology.eom 2010 11 9 R94 w Genome Biology RESEARCH Open Access Sequence and structure of Brassica rapa chromosome A3 1 t 1 t 111 1 1 Jeong-Hwan Mun Soo-Jin Kwon Young-Joo Seol Jin A Kim Mina Jin Jung Sun Kim Myung-Ho Lim 111 111 1 Soo-In Lee Joon Ki Hong Tae-Ho Park Sang-Choon Lee Beom-Jin Kim Mi-Suk Seo Seunghoon Baek 111 2 2 3 Min-Jee Lee Ja Young Shin Jang-Ho Hahn Yoon-Jung Hwang Ki-Byung Lim Jee Young Park Jonghoon Lee3 Tae-Jin Yang3 Hee-Ju Yu4 Ik-Young Choi5 Beom-Soon Choi5 Su Ryun Choi6 Nirala Ramchiary6 Yong Pyo Lim6 Fiona Fraser7 Nizar Drou7 Eleni Soumpourou7 Martin Trick7 Ian Bancroft7 Andrew G Sharpe8 9 10 11 1 Isobel AP Parkin Jacqueline Batley Dave Edwards Beom-Seok Park Abstract Background The species Brassica rapa includes important vegetable and oil crops. It also serves as an excellent model system to study polyploidy-related genome evolution because of its paleohexaploid ancestry and its close evolutionary relationships with Arabidopsis thaliana and other Brassica species with larger genomes. Therefore its genome sequence will be used to accelerate both basic research on genome evolution and applied research across the cultivated Brassica species. Results We have determined and analyzed the sequence of B. rapa chromosome A3. We obtained 31.9 Mb of sequences organized into nine contigs which incorporated 348 overlapping BAC clones. Annotation revealed 7 058 protein-coding genes with an average gene density of 4.6 kb per gene. Analysis of chromosome collinearity with the A. thaliana genome identified conserved synteny blocks encompassing the whole of the B. rapa chromosome A3 and sections of four A. thaliana chromosomes. The frequency of tandem duplication of genes differed between the conserved genome segments in B. rapa and A. thaliana indicating differential rates of occurrence retention of such duplicate copies of genes. Analysis of ancestral karyotype genome building blocks enabled the .