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Báo cáo y học: "Homoeolog-specific retention and use in allotetraploid Arabidopsis suecica depends on parent of origin and network partners"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Homoeolog-specific retention and use in allotetraploid Arabidopsis suecica depends on parent of origin and network partners. | Chang et al. Genome Biology 2010 11 R125 http genomebiology.com 2010 11 12 R125 Genome Biology RESEARCH Open Access Homoeolog-specific retention and use in allotetraploid Arabidopsis suecica depends on parent of origin and network partners Pdtdr I chann 1 Rrian D riillzcic2 3 f. licfsollo l lnK labmo4 I I me nmai2 fzivim Ml I 7bdin1 reter L Chany Brian r LVilkes Michelle McMahon Luca Co Mdl Sergey V Nuzhdin Abstract Background Allotetraplolds carry pairs of diverged homoeologs for most genes. With the genome doubled in size the number of putative interactions is enormous. This poses challenges on how to coordinate the two disparate genomes and creates opportunities by enhancing the phenotypic variation. New combinations of alleles co-adapt and respond to new environmental pressures. Three stages of the allopolyploidization process - parental species divergence hybridization and genome duplication - have been well analyzed. The last stage of evolutionary adjustments remains mysterious. Results Homoeolog-specific retention and use were analyzed in Arabidopsis suecica As a species derived from A. thaliana At and A. arenosa Aa in a single event 12 000 to 300 000 years ago. We used 405 466 diagnostic features on tiling microarrays to recognize At and Aa contributions to the As genome and transcriptome 324 genes lacked Aa contributions and 614 genes lacked At contributions within As. In leaf tissues 3 458 genes preferentially expressed At homoeologs while 4 150 favored Aa homoeologs. These patterns were validated with resequencing. Genes with preferential use of Aa homoeologs were enriched for expression functions consistent with the dominance of Aa transcription. Heterologous networks - mixed from At and Aa transcripts - were underrepresented. Conclusions Thousands of deleted and silenced homoeologs in the genome of As were identified. Since heterologous networks may be compromised by interspecies incompatibilities these networks evolve co-biases expressing either only