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Báo cáo y học: "Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation | Chistiakov Journal of Biomedical Science 2010 17 92 http www.jbiomedsci.eom content 17 1 92 NSC The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE REVIEW Open Access Endogenous and exogenous stem cells a role in lung repair and use in airway tissue engineering and transplantation Dimitry A Chistiakov Abstract Rapid repair of the denuded alveolar surface after injury is a key to survival. The respiratory tract contains several sources of endogenous adult stem cells residing within the basal layer of the upper airways within or near pulmonary neuroendocrine cell rests at the bronchoalveolar junction and within the alveolar epithelial surface which contribute to the repair of the airway wall. Bone marrow-derived adult mesenchymal stem cells circulating in blood are also involved in tracheal regeneration. However an organism is frequently incapable of repairing serious damage and defects of the respiratory tract resulting from acute trauma lung cancers and chronic pulmonary and airway diseases. Therefore replacement of the tracheal tissue should be urgently considered. The shortage of donor trachea remains a major obstacle in tracheal transplantation. However implementation of tissue engineering and stem cell therapy-based approaches helps to successfully solve this problem. To date huge progress has been achieved in tracheal bioengineering. Several sources of stem cells have been used for transplantation and airway reconstitution in animal models with experimentally induced tracheal defects. Most tracheal tissue engineering approaches use biodegradable three-dimensional scaffolds which are important for neotracheal formation by promoting cell attachment cell redifferentiation and production of the extracellular matrix. The advances in tracheal bioengineering recently resulted in successful transplantation of the world s first bioengineered trachea. Current trends in tracheal .