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Báo cáo y học: "Bacterial and fungal microflora in surgically removed lung cancer samples."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Bacterial and fungal microflora in surgically removed lung cancer samples. | Apostolou et al. Journal of Cardiothoracic Surgery 2011 6 137 http www.cardiothoracicsurgery.Org content 6 1 137 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Bacterial and fungal microflora in surgically removed lung cancer samples Panagiotis Apostolou1 Aggeliki Tsantsaridou2 loannis Papasotiriou1 Maria Toloudi1 Marina Chatziioannou1 and Gregory Giamouzis3 Abstract Background Clinical and experimental data suggest an association between the presence of bacterial and or fungal infection and the development of different types of cancer independently of chemotherapy-induced leukopenia. This has also been postulated for the development of lung cancer however the prevalence and the exact species of the bacteria and fungi implicated have not yet been described. Aim To determine the presence of bacterial and fungal microflora in surgically extracted samples of patients with lung cancer. Materials and methods In this single-center prospective observational study tissue samples were surgically extracted from 32 consecutive patients with lung cancer and reverse-transcription polymerase chain reaction RT-PCR was used to identify the presence of bacteria and fungi strains. Results The analysis of the electrophoresis data pointed out diversity between the samples and the strains that were identified. Mycoplasma strains were identified in all samples. Strains that appeared more often were Staphylococcus epidermidis Streptococcus mitis and Bacillus strains followed in descending frequency by Chlamydia Candida Listeria and Haemophilus influenza. In individual patients Legionella pneumophila and Candida tropicalis were detected. Conclusions A diversity of pathogens could be identified in surgically extracted tissue samples of patients with lung cancer with mycoplasma strains being present in all samples. These results point to an etiologic role for chronic infection in lung carcinogenesis. Confirmation of these observations and additional studies are needed .