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Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer. | Hanagiri et al. Journal of Cardiothoracic Surgery 2011 6 144 http www.cardiothoracicsurgery.Org content 6 1 144 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer Takeshi Hanagiri Masaru Takenaka Soich Oka Yoshiki Shigematsu Yoshika Nagata Hidehiko Shimokawa Hidetaka Uramoto and Fumihiro Tanaka Abstract Purpose This study investigated whether the number of involved lymph nodes is associated with the prognosis in patients that underwent surgery for pathological stage p-stage III N2 NSCLC. Subjects This study evaluated 121 patients with p-stage III N2 NSCLC. Results The histological types included 65 adenocarcinomas 39 squamous cell carcinomas and 17 others. The average number of dissected lymph nodes was 23.8 range 6-55 . The average number of involved lymph nodes was 5.9 range 1-23 . The 5-year survival rate of the patients was 51.0 for single lymph node positive 58.9 for 2 lymph nodes positive 34.2 for 3 lymph nodes positive and 30.0 for 4 lymph nodes positive and 20.4 for more than 5 lymph nodes positive. The patients with either single or 2 lymph nodes positive had a significantly more favorable prognosis than the patients with more than 5 lymph nodes positive. A multivariate analysis revealed that the number of involved lymph nodes was a significant independent prognostic factor. Conclusion Surgery appears to be preferable as a one arm of multimodality therapy in p-stage III N2 patients with single or 2 involved lymph nodes. The optimal incorporation of surgery into the multimodality approach therefore requires further clinical investigation. Keywords non-small cell lung cancer surgical resection mediastial lymph node metastasis number of involved lymph nodes skip metastasis postoperative prognosis Introduction More than 1.6 million new cases of lung cancer are diagnosed worldwide each year .